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猪场“万能药”地塞米松不可乱用用错要猪命!

时间:2019-05-29 11:12来源:未知 作者:admin 点击:
地塞米松对病原微生物没有抑制作用,其抗炎、抗过敏和抗休克等药理作用是通过抑制机体的炎症反应和免疫反应来实现的,所以,它能诱发新的感染和加重原有感染,造成免疫失败或

  地塞米松对病原微生物没有抑制作用,其抗炎、抗过敏和抗休克等药理作用是通过抑制机体的炎症反应和免疫反应来实现的,所以,它能诱发新的感染和加重原有感染,造成免疫失败或降低抗体水平。用药时间越长,越易发生感染扩散,增加疫病继发、并发的机会。

  在治疗高致死性猪蓝耳病、圆环病毒病、支原体肺炎等免疫抑制性猪病时,滥用地塞米松会直接导致病猪防御机能崩溃,成为加速病猪死亡的重要因素。持续大剂量使用地塞米松,会使畜体出现水肿、低血钾、肌肉萎缩、幼畜生长停滞、骨质疏松等类似肾上腺皮质功能亢进的表现,突然停药后又出现食欲不振、精神抑郁、发热、血糖下降等肾上腺皮质功能不全症状。

  母猪妊娠早期使用地塞米松,会影响胎儿发育甚至致畸形胎儿,后期会引起流产。

  地塞米松不能用于无有效抗菌药物治疗的病毒、霉菌、耐药菌株感染以及外毒素所引起的疾病。

  地塞米松可以通过血胎屏障,严重抑制胚胎生长发育,从而导致胎儿畸形,甚至死胎木乃伊。此外还具有兴奋子宫平滑肌的作用,可使子宫收缩,导致流产。

  地塞米松可使机体蛋白质异生和抑制蛋白质合成而影响抗体生成,间接影响抗体的生成,影响疫苗免疫效价,造成抗体水平降低,从而影响免疫效果,甚至引起免疫失败。

  地塞米松使用时间越长,越容易发生感染扩散,增加疾病继发、并发的机会,尤其是一些复杂的隐性感染。故应尽量采用最小有效剂量,病情一经控制即应减量或停药。

  1、妊娠期母猪慎用。因为会兴奋子宫平滑肌,增强子宫自发性收缩,导致妊娠母猪出现流产。还可能让胎盘功能不全,阻碍胎儿的生长发育,让胎儿畸形畸形胎,甚至死亡。

  2、在接种疫苗时禁用,因为会影响疫苗免疫效价,降低疫苗的免疫效果或不起作用。

  4、长时间使用要适当补充磷、钙,预防出现骨质疏松和新陈代谢紊乱;新生的幼畜禁用,产后瘫痪和年龄大的猪慎用。

  5、地塞米松不能久用,也不能减量过快或骤停,不然猪出现食欲不振、精神沉郁,体温升高,呕吐,软弱无力,低血糖,低血压,有的猪还会出现休克现象。

  6、地塞米松使用中应注意减量渐停,防止因突然停药而出现低血压、低血糖、休克等,使病情反复或加重。

  地塞米松的禁用事项还有很多,养殖朋友在使用时一定要注意,以免因小失大,造成不必要的损失。

  1、较强的抗炎作用:对细菌、病毒、真菌等感染及其他物理的、化学的、免疫性等因素引起的炎症反应过程均有抑制作用,可减轻和防止急性炎症期的炎症渗出、水肿和炎症细胞浸润,如用在治疗关节炎关节风湿病的急性期效果较好,对产后感染、恶露不净、体温升高、食欲不振等配合抗生素也有很好的效果,在治疗母猪乳房炎的时候也有较好的消炎效果,但剂量要掌握好,超量会有产奶量下降的现象。

  2、免疫抑制作用:利用免疫抑制作用可治疗过敏反应性疾病及休克,但疫苗接种期间禁用,对自身免疫性疾病及血液病如仔猪溶血性贫血、皮炎—肾病综合征等有效。

  3、抗毒素作用:地塞米松能保持细胞膜的完整性,降低细胞膜的通透性,从而使内毒素不易透入细胞内,提高机体对有害刺激的应激能力,减轻毒素对机体的损害,缓解毒血症,对毒血症的高热有良好的退热作用。

  4、抗休克作用:能提高血小管的能力,加强心肌性缩力增加血液输出量,回升血压,有利于感染性休克、内毒素性休克、低血容量性休克、心源性休克等的纠正,用于危重病例的抢救等。

  5、抗过敏作用:能减少过敏介质的产生及释放,故可减轻过敏反应(超敏反应)症状,如注射疫苗引起的过敏、荨麻疹、特异反应性皮炎等。

  1、猪鼻炎、喉炎:由于粘膜肿胀引起腔道狭窄,造成呼吸障碍,单纯应用抗菌素效果不好,或见效太慢,配合使用大剂量地塞米松可获立竿见影之效。

  2、猪患血液原虫病,如附红细胞体,红细胞被破坏,毒素大量产出但排不出体外,造成血液中毒。虽然使用大量使用抗原虫药物但效果不好时,同时配合使用大剂量地塞米松可很快减轻病猪临床症状,大大缩短治愈时间。……

  3、猪患肺炎,如急性胸膜肺炎,炎症较重,单纯使用抗菌素效果太慢,需多次大剂量才见效,而且会因大剂量注射药物有较大副作用,此时配合大剂量地塞米松,可很快控制肺部炎症,减少渗出,缩短治疗时间。

  以上几种情况是利用了地塞米松较强的抗炎抗毒素作用,注意使用大剂量地塞米松时,必须配合足量敏感的抗菌素,否则病情会很快恶化,并且要根据病情逐渐减量。

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o=;returnboolean==typeof e&&(n=t,t=e,r=n,i=r,e=null),login==s?o=0:reg==s&&(o=2),(new c({o:User,m:sendSmsCodeNew,condition:t?1:2,account:n,crumb:e,sms_scene:o,captcha:r,vt:i})).post()},sendSmsToken:function(e,t,n,r){var i=;returnboolean==typeof e&&(n=t,t=e,e=null),object==typeof n&&(n=n.areaCode+n.mobileNumber),findpwd==r&&(i=1),(new c({o:User,m:sendSmsCode,condition:t?1:2,account:n,crumb:e,sms_scene:i})).post()},sendEmailToken:function(e,t){return(new c({o:User,m:sendEmsCode,condition:1,crumb:e,vtype:t})).post()},sendActivationEmail:function(e){var t=new c({crumb:e});return t.post(t.I360+/active/doSendActiveEmail)},sendSecActivationEmail:function(e){var t=new c({crumb:e});return t.post(t.I360+/profile/resendSecurityEmail)},sendSignUpActivationEmail:function(e){return(new c).get(e)},bindMobile:function(e,t,n){var t=t.areaCode+t.mobileNumber;return(new c({o:user,m:bindMobile,crumb:e,mobile:t,smscode:n},{},!0)).post().done(function(){u()})},signUp:function(t){var n={captchaFlag:!0,captchaApp:e.getConfig(captchaAppId,i360),smDeviceId:i()};t=a.extend(n,t),t.password=r(t.password),t.passwordAgain=r(t.passwordAgain)t.password,o(t,{emailActiveFlag:loginEmailActiveFlag,passwordAgain:rePassword,smsToken:smscode,nickname:nickName,username:userName,agreeLicence:is_agree});var s=new c(t,{},!0);return s.post(s.I360+/reg/doregAccount).done(function(){u()})},signIn:function(t){var n={o:sso,m:login,lm:mobile==t.type?1:0,captFlag:1,rtype:data,validatelm:e.getConfig(signIn.mobile.isMustUseMobileSignIn,!1)?1:0,isKeepAlive:!1,captchaApp:e.getConfig(captchaAppId,i360),userName:t.account,smDeviceId:i()};returnmobile==t.type?t.acctype=2:t.password=r(t.password),a.when().then(function(){return t.tokene.sync.getToken(t.account).done(function(e){t.token=e.token})}).then(function(){return(new c(a.extend(n,t),{},!0)).post().done(function(){u()})}).then(function(t){return e.sync.setCookie(t.s)}).then(function(){return e.getUserInfo(!1)})},signOut:function(t){var n=e.getConfig(supportHttps,l),r=https==e.getConfig(protocol,null).toLowerCase();void 0===t!0===t?t=e.getConfig(domainList,[]):a.isArray(t)(t=[t]);var i,s=[];return a.each(t,function(e,t){a.inArray(t,n)>

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